A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis
mir-17-92, a potent polycistronic oncomir, encodes six mature miRNAs with complex modes of interactions. In the Eμ-myc Burkitt’s lymphoma model, mir-17-92 exhibits potent oncogenic activity by repressing c-Myc-induced apoptosis, primarily through its miR-19 components. Surprisingly, mir-17-92 also e...
Main Authors: | , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2013-10-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/00822 |