HIV-1 infected humanized DRAGA mice develop HIV-specific antibodies despite lack of canonical germinal centers in secondary lymphoid tissues

HIV-1 infected humanized DRAGA mice develop HIV-specific antibodies despite lack of canonical germinal centers in secondary lymphoid tissues

A major barrier in the use of humanized mice as models of HIV-1 (HIV) infection is the inadequate generation of virus-specific antibody responses. Humanized DRAGA (hDRAGA) mice generate antigen-specific class switched antibodies to several pathogens, but whether they do so in HIV infection and the e...

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Bibliographic Details
Main Authors: Matthew T. Ollerton, Joy M. Folkvord, Kristina K. Peachman, Soumya Shashikumar, Elaine B. Morrison, Linda L. Jagodzinski, Sheila A. Peel, Mohammad Khreiss, Richard T. D’Aquila, Sofia Casares, Mangala Rao, Elizabeth Connick
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
humanized DRAGA mice
HIV - human immunodeficiency virus
secondary lymphoid tissue
germinal center (GC)
follicle
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1047277/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1047277/full

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