The Carcinogen Cadmium Activates Lysine 63 (K63)-Linked Ubiquitin-Dependent Signaling and Inhibits Selective Autophagy

The Carcinogen Cadmium Activates Lysine 63 (K63)-Linked Ubiquitin-Dependent Signaling and Inhibits Selective Autophagy

Signaling, proliferation, and inflammation are dependent on K63-linked ubiquitination—conjugation of a chain of ubiquitin molecules linked via lysine 63. However, very little information is currently available about how K63-linked ubiquitination is subverted in cancer. The present study provides, fo...

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Bibliographic Details
Main Authors: Abderrahman Chargui, Amine Belaid, Papa Diogop Ndiaye, Véronique Imbert, Michel Samson, Jean-Marie Guigonis, Michel Tauc, Jean-François Peyron, Philippe Poujeol, Patrick Brest, Paul Hofman, Baharia Mograbi
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
K63-linked ubiquitination
tumor suppression
selective autophagy
starvation-induced autophagy
aggrephagy
CYLD deubiquitinase
Online Access:https://www.mdpi.com/2072-6694/13/10/2490

Internet

https://www.mdpi.com/2072-6694/13/10/2490

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