Auranofin Inhibits the Enzyme Activity of Pasteurella multocida Toxin PMT in Human Cells and Protects Cells from Intoxication

Auranofin Inhibits the Enzyme Activity of Pasteurella multocida Toxin PMT in Human Cells and Protects Cells from Intoxication

The AB-type protein toxin from Pasteurella multocida (PMT) contains a functionally important disulfide bond within its catalytic domain, which must be cleaved in the host cell cytosol to render the catalytic domain of PMT into its active conformation. Here, we found that the reductive potential of t...

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Bibliographic Details
Main Authors: Stefan Carle, Thorsten Brink, Joachim H. C. Orth, Klaus Aktories, Holger Barth
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:Toxins
Subjects:
Pasteurella multocida toxin (PMT)
deamidation
G-protein
thioredoxin reductase (TrxR)
auranofin
Online Access:http://www.mdpi.com/2072-6651/9/1/32

Internet

http://www.mdpi.com/2072-6651/9/1/32

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