The Antitumoral/Antimetastatic Action of the Flavonoid Brachydin A in Metastatic Prostate Tumor Spheroids In Vitro Is Mediated by (Parthanatos) PARP-Related Cell Death

The Antitumoral/Antimetastatic Action of the Flavonoid Brachydin A in Metastatic Prostate Tumor Spheroids In Vitro Is Mediated by (Parthanatos) PARP-Related Cell Death

Metastatic prostate cancer (mPCa) is resistant to several chemotherapeutic agents. Brachydin A (BrA), a glycosylated flavonoid extracted from <i>Fridericia platyphylla</i>, displays a remarkable antitumoral effect against in vitro mPCa cells cultured as bidimensional (2D) monolayers. Con...

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Bibliographic Details
Main Authors: Diego Luis Ribeiro, Katiuska Tuttis, Larissa Cristina Bastos de Oliveira, Juliana Mara Serpeloni, Izabela Natalia Faria Gomes, André van Helvoort Lengert, Cláudia Quintino da Rocha, Rui Manuel Reis, Ilce Mara de Syllos Cólus, Lusânia Maria Greggi Antunes
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceutics
Subjects:
<i>Fridericia platyphylla</i>
prostate cancer
chemotherapy
tumor spheroids
cell death
Online Access:https://www.mdpi.com/1999-4923/14/5/963

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https://www.mdpi.com/1999-4923/14/5/963

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