Neuronal miR-9 promotes HSV-1 epigenetic silencing and latency by repressing Oct-1 and Onecut family genes

Neuronal miR-9 promotes HSV-1 epigenetic silencing and latency by repressing Oct-1 and Onecut family genes

Abstract Herpes simplex virus 1 (HSV-1) latent infection entails repression of viral lytic genes in neurons. By functional screening using luciferase-expressing HSV-1, we identify ten neuron-specific microRNAs potentially repressing HSV-1 neuronal replication. Transfection of miR-9, the most active...

Full description

Bibliographic Details
Main Authors: Yue Deng, Yuqi Lin, Siyu Chen, Yuhang Xiang, Hongjia Chen, Shuyuan Qi, Hyung Suk Oh, Biswajit Das, Gloria Komazin-Meredith, Jean M. Pesola, David M. Knipe, Donald M. Coen, Dongli Pan
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46057-6

Internet

https://doi.org/10.1038/s41467-024-46057-6

Similar Items