HMGB1 in the mPFC governs comorbid anxiety in neuropathic pain

HMGB1 in the mPFC governs comorbid anxiety in neuropathic pain

Abstract Background Whether neuroinflammation causes comorbid mood disorders in neuropathic pain remains elusive. Here we investigated the role of high mobility group box 1 protein (HMGB1), a proinflammatory cytokine, in the medial prefrontal cortex (mPFC) in anxiety comorbidity of neuropathic pain....

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Bibliographic Details
Main Authors: Yu Du, Ceng-Lin Xu, Jie Yu, Keyue Liu, Shi-Da Lin, Ting-Ting Hu, Feng-Hui Qu, Fang Guo, Guo-Dong Lou, Masahiro Nishibori, Wei-Wei Hu, Zhong Chen, Shi-Hong Zhang
Format: Article
Language:English
Published: BMC 2022-08-01
Series:The Journal of Headache and Pain
Subjects:
HMGB1
Neuroinflammation
mPFC
Neuropathic pain
Comorbid mood disorders
Anxiety
Online Access:https://doi.org/10.1186/s10194-022-01475-z

Internet

https://doi.org/10.1186/s10194-022-01475-z

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