Structural relationship of the lipid A acyl groups to activation of murine Toll-like receptor 4 by lipopolysaccharides from pathogenic strains of Burkholderia mallei, Acinetobacter baumannii and Pseudomonas aeruginosa

Structural relationship of the lipid A acyl groups to activation of murine Toll-like receptor 4 by lipopolysaccharides from pathogenic strains of Burkholderia mallei, Acinetobacter baumannii and Pseudomonas aeruginosa

Toll-like receptor 4 (TLR4) is required for activation of innate immunity upon recognition of lipopolysaccharide (LPS) of Gram-negative bacteria. The ability of TLR4 to respond to a particular LPS species is important since insufficient activation may not prevent bacterial growth while excessive imm...

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Bibliographic Details
Main Authors: Kirill V Korneev, Nikolay P Arbatsky, Antonio eMolinaro, Angelo ePalmigiano, Rima Z Shaikhutdinova, Mikhail M Shneider, Gerald B Pier, Anna N Kondakova, Ekaterina N Sviriaeva, Luisa eSturiale, Domenico eGarozzo, Andrey A Kruglov, Sergei A Nedospasov, Marina S Drutskaya, Yuriy A Knirel, Dmitry V Kuprash
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Immunology
Subjects:
Gram-Negative Bacteria
Lipid A
Macrophages
innate immunity
proinflammatory cytokines
acyl chains
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00595/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00595/full

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