Hepatocyte ABCA1 deficiency is associated with reduced HDL sphingolipids

Hepatocyte ABCA1 deficiency is associated with reduced HDL sphingolipids

ATP binding cassette transporter A1 (ABCA1) limits the formation of high density lipoproteins (HDL) as genetic loss of ABCA1 function causes virtual HDL deficiency in patients with Tangier disease. Mice with a hepatocyte-specific ABCA1 knockout (Abca1 HSKO) have 20% of wild type (WT) plasma HDL-chol...

Full description

Bibliographic Details
Main Authors: Alaa Othman, Mingxia Liu, Heiko Bode, Elena Boudyguina, Arnold von Eckardstein, John S. Parks, Thorsten Hornemann
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Physiology
Subjects:
sphingolipids
Tangier disease
serine-palmitoyltransferase
HDL
LDL
lipoprotein
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1208719/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2023.1208719/full

Similar Items