MMP mediated degradation of type IV collagen alpha 1 and alpha 3 chains reflects basement membrane remodeling in experimental and clinical fibrosis--validation of two novel biomarker assays.

MMP mediated degradation of type IV collagen alpha 1 and alpha 3 chains reflects basement membrane remodeling in experimental and clinical fibrosis--validation of two novel biomarker assays.

OBJECTIVES: Fibrosis is characterized by excessive tissue remodeling resulting from altered expression of various growth factors, cytokines and proteases. We hypothesized that matrix metalloproteinase (MMP) mediated degradation of type IV collagen, a main component of the basement membrane, will rel...

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Bibliographic Details
Main Authors: Jannie Marie Sand, Lise Larsen, Cory Hogaboam, Fernando Martinez, Meilan Han, Martin Røssel Larsen, Arkadiusz Nawrocki, Qinlong Zheng, Morten Asser Karsdal, Diana Julie Leeming
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3871599?pdf=render

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http://europepmc.org/articles/PMC3871599?pdf=render

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