Genome-wide characterization of dynamic DNA 5-hydroxymethylcytosine and TET2-related DNA demethylation during breast tumorigenesis

Genome-wide characterization of dynamic DNA 5-hydroxymethylcytosine and TET2-related DNA demethylation during breast tumorigenesis

Abstract Background Breast tumorigenesis is a complex and multistep process accompanied by both genetic and epigenetic dysregulation. In contrast to the extensive studies on DNA epigenetic modifications 5-hydroxymethylcytosine (5hmC) and 5-methylcytosine (5mC) in malignant breast tumors, their roles...

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Bibliographic Details
Main Authors: Shuang-Ling Wu, Lin Yang, Changcai Huang, Qing Li, Chunhui Ma, Fang Yuan, Yinglin Zhou, Xiaoyue Wang, Wei-Min Tong, Yamei Niu, Feng Jin
Format: Article
Language:English
Published: BMC 2024-09-01
Series:Clinical Epigenetics
Subjects:
Breast tumorigenesis
DNA 5-hydroxymethylcytosine
5-methylcytosine
DNA methylation
DNA demethylation
TET2
Online Access:https://doi.org/10.1186/s13148-024-01726-7

Internet

https://doi.org/10.1186/s13148-024-01726-7

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