Sustained overexpression of spliced X-box-binding protein-1 in neurons leads to spontaneous seizures and sudden death in mice

Sustained overexpression of spliced X-box-binding protein-1 in neurons leads to spontaneous seizures and sudden death in mice

XBP1s is a key effector of the unfolded protein response. Neuron-specific overexpression of Xbp1s in the brain leads to impaired GABAergic signaling and recurrent spontaneous seizures in mice.

Bibliographic Details
Main Authors: Zhuoran Wang, Qiang Li, Brad J. Kolls, Brian Mace, Shu Yu, Xuan Li, Wei Liu, Eduardo Chaparro, Yuntian Shen, Lihong Dang, Ángela del Águila, Joshua D. Bernstock, Kory R. Johnson, Junjie Yao, William C. Wetsel, Scott D. Moore, Dennis A. Turner, Wei Yang
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04594-8

Internet

https://doi.org/10.1038/s42003-023-04594-8

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