Sustained overexpression of spliced X-box-binding protein-1 in neurons leads to spontaneous seizures and sudden death in mice
XBP1s is a key effector of the unfolded protein response. Neuron-specific overexpression of Xbp1s in the brain leads to impaired GABAergic signaling and recurrent spontaneous seizures in mice.
Main Authors: | Zhuoran Wang, Qiang Li, Brad J. Kolls, Brian Mace, Shu Yu, Xuan Li, Wei Liu, Eduardo Chaparro, Yuntian Shen, Lihong Dang, Ángela del Águila, Joshua D. Bernstock, Kory R. Johnson, Junjie Yao, William C. Wetsel, Scott D. Moore, Dennis A. Turner, Wei Yang |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-03-01
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Series: | Communications Biology |
Online Access: | https://doi.org/10.1038/s42003-023-04594-8 |
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