A Semiquantitative Non-invasive Measurement of PcomA Patency in C57BL/6 Mice Explains Variance in Ischemic Brain Damage in Filament MCAo

A Semiquantitative Non-invasive Measurement of PcomA Patency in C57BL/6 Mice Explains Variance in Ischemic Brain Damage in Filament MCAo

Numerous studies on experimental ischemic stroke use the filament middle cerebral artery occlusion (fMCAo) model in C57BL/6 mice, but lesion sizes in this strain are highly variable. A known contributor is variation in the posterior communicating artery (PcomA) patency. We therefore aimed to provide...

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Bibliographic Details
Main Authors: Samuel Knauss, Carolin Albrecht, Ulrich Dirnagl, Susanne Mueller, Christoph Harms, Christian Johannes Hoffmann, Stefan Paul Koch, Matthias Endres, Philipp Boehm-Sturm
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Neuroscience
Subjects:
stroke
mouse
angiography
MRI
posterior communicating artery
lesion size
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.576741/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.576741/full

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