Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics

Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics

Mesothelin is a glypiated, cell-surface glycoprotein expressed at low levels on normal mesothelium but overexpressed by many cancers. Implicated in cell adhesion and multiple signaling pathways, mesothelin’s precise biological function and overall structure remain undefined. Antibodies targeting mes...

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Bibliographic Details
Main Authors: Ida Lin, Peter B. Rupert, Kristina Pilat, Raymond O. Ruff, Della J. Friend, Man Kid Chan, Midori Clarke, Benjamin G. Hoffstrom, Jane Carter, Soheil Meshinchi, Ashok D. Bandaranayake, Christopher Mehlin, James M. Olson, Roland K. Strong, Colin E. Correnti
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Drug Discovery
Subjects:
mesothelin
antibody
CD3
bispecific
T cell
cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fddsv.2023.1216516/full

Internet

https://www.frontiersin.org/articles/10.3389/fddsv.2023.1216516/full

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