Targeting glutamine utilization to block metabolic adaptation of tumor cells under the stress of carboxyamidotriazole-induced nutrients unavailability

Targeting glutamine utilization to block metabolic adaptation of tumor cells under the stress of carboxyamidotriazole-induced nutrients unavailability

Tumor cells have unique metabolic programming that is biologically distinct from that of corresponding normal cells. Resetting tumor metabolic programming is a promising strategy to ameliorate drug resistance and improve the tumor microenvironment. Here, we show that carboxyamidotriazole (CAI), an a...

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Bibliographic Details
Main Authors: Jing Shi, Rui Ju, Hongting Gao, Yuqing Huang, Lei Guo, Dechang Zhang
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:Acta Pharmaceutica Sinica B
Subjects:
CAI
Glutaminolysis
Glutamine metabolism
AhR
Colorectal cancer metabolism
Mitochondrial oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521002574

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http://www.sciencedirect.com/science/article/pii/S2211383521002574

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