XRN2 Links Transcription Termination to DNA Damage and Replication Stress.

XRN2 Links Transcription Termination to DNA Damage and Replication Stress.

XRN2 is a 5'-3' exoribonuclease implicated in transcription termination. Here we demonstrate an unexpected role for XRN2 in the DNA damage response involving resolution of R-loop structures and prevention of DNA double-strand breaks (DSBs). We show that XRN2 undergoes DNA damage-inducible...

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Bibliographic Details
Main Authors: Julio C Morales, Patricia Richard, Praveen L Patidar, Edward A Motea, Tuyen T Dang, James L Manley, David A Boothman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4954731?pdf=render

Internet

http://europepmc.org/articles/PMC4954731?pdf=render

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