Inactivating Mutations of the <i>IK</i> Gene Weaken Ku80/Ku70-Mediated DNA Repair and Sensitize Endometrial Cancer to Chemotherapy

Inactivating Mutations of the <i>IK</i> Gene Weaken Ku80/Ku70-Mediated DNA Repair and Sensitize Endometrial Cancer to Chemotherapy

IK is a mitotic factor that promotes cell cycle progression. Our previous investigation of 271 endometrial cancer (EC) samples from the Cancer Genome Atlas (TCGA) dataset showed IK somatic mutations were enriched in a cluster of patients with high-grade and high-stage cancers, and this group had lon...

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Bibliographic Details
Main Authors: Chao Gao, Guangxu Jin, Elizabeth Forbes, Lingegowda S. Mangala, Yingmei Wang, Cristian Rodriguez-Aguayo, Paola Amero, Emine Bayraktar, Ye Yan, Gabriel Lopez-Berestein, Russell R. Broaddus, Anil K. Sood, Fengxia Xue, Wei Zhang
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
IK
somatic mutation
DNA repair
endometrial cancer
Ku80
cisplatin
Online Access:https://www.mdpi.com/2072-6694/13/10/2487

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https://www.mdpi.com/2072-6694/13/10/2487

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