Characterization of Ku70(2)-NLS as bipartite nuclear localization sequence for non-viral gene delivery.

Characterization of Ku70(2)-NLS as bipartite nuclear localization sequence for non-viral gene delivery.

Several barriers have to be overcome in order to achieve gene expression in target cells, e.g. cellular uptake, endosomal release and translocation to the nucleus. Nuclear localization sequences (NLS) enhance gene delivery by increasing the uptake of plasmid DNA (pDNA) to the nucleus. So far, only m...

Full description

Bibliographic Details
Main Authors: Johannes Matschke, Alexander Bohla, Christof Maucksch, Rashmi Mittal, Carsten Rudolph, Joseph Rosenecker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3275586?pdf=render

Internet

http://europepmc.org/articles/PMC3275586?pdf=render

Similar Items