Hypoxic postconditioning restores mitophagy against transient global cerebral ischemia via Parkin-induced posttranslational modification of TBK1

Hypoxic postconditioning restores mitophagy against transient global cerebral ischemia via Parkin-induced posttranslational modification of TBK1

Hypoxic postconditioning (HPC) has been reported to enhance Parkin-catalyzed mitochondrial ubiquitination to restore mitophagy in hippocampal CA1 against transient global cerebral ischemia (tGCI). However, the molecular mechanism leading ubiquitinated mitochondria to final clearance during HPC-media...

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Bibliographic Details
Main Authors: Haixia Wen, Yunyan Zuo, Luxi Li, Lixuan Zhan, Jiahui Xue, Weiwen Sun, En Xu
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Neurobiology of Disease
Subjects:
Transient global cerebral ischemia
Hypoxic postconditioning
Neuroprotection
Parkin-dependent mitophagy
TBK1
Posttranslational modification
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123000578

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http://www.sciencedirect.com/science/article/pii/S0969996123000578

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