Hypoxic postconditioning restores mitophagy against transient global cerebral ischemia via Parkin-induced posttranslational modification of TBK1

Hypoxic postconditioning restores mitophagy against transient global cerebral ischemia via Parkin-induced posttranslational modification of TBK1

Hypoxic postconditioning (HPC) has been reported to enhance Parkin-catalyzed mitochondrial ubiquitination to restore mitophagy in hippocampal CA1 against transient global cerebral ischemia (tGCI). However, the molecular mechanism leading ubiquitinated mitochondria to final clearance during HPC-media...

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Bibliographic Details
Main Authors:	Haixia Wen, Yunyan Zuo, Luxi Li, Lixuan Zhan, Jiahui Xue, Weiwen Sun, En Xu
Format:	Article
Language:	English
Published:	Elsevier 2023-04-01
Series:	Neurobiology of Disease
Subjects:	Transient global cerebral ischemia Hypoxic postconditioning Neuroprotection Parkin-dependent mitophagy TBK1 Posttranslational modification
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996123000578

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