Extracellular Spermine Activates DNA Methyltransferase 3A and 3B

Extracellular Spermine Activates DNA Methyltransferase 3A and 3B

We first demonstrated that long-term increased polyamine (spermine, spermidine, putrescine) intake elevated blood spermine levels in mice and humans, and lifelong consumption of polyamine-rich chow inhibited aging-associated increase in aberrant DNA methylation, inhibited aging-associated pathologic...

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Bibliographic Details
Main Authors: Taro Fukui, Kuniyasu Soda, Koichi Takao, Toshiki Rikiyama
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
gene methylation
methyltransferase
DNA methyltransferase (DNMT)
polyamine
spermine
ornithine decarboxylase (ODC)
D,L-alpha-difluoromethylornithine (DFMO)
adenosylmethionine
Online Access:http://www.mdpi.com/1422-0067/20/5/1254

Internet

http://www.mdpi.com/1422-0067/20/5/1254

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