Extracellular Spermine Activates DNA Methyltransferase 3A and 3B

Extracellular Spermine Activates DNA Methyltransferase 3A and 3B

We first demonstrated that long-term increased polyamine (spermine, spermidine, putrescine) intake elevated blood spermine levels in mice and humans, and lifelong consumption of polyamine-rich chow inhibited aging-associated increase in aberrant DNA methylation, inhibited aging-associated pathologic...

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Bibliographic Details
Main Authors:	Taro Fukui, Kuniyasu Soda, Koichi Takao, Toshiki Rikiyama
Format:	Article
Language:	English
Published:	MDPI AG 2019-03-01
Series:	International Journal of Molecular Sciences
Subjects:	gene methylation methyltransferase DNA methyltransferase (DNMT) polyamine spermine ornithine decarboxylase (ODC) D,L-alpha-difluoromethylornithine (DFMO) adenosylmethionine
Online Access:	http://www.mdpi.com/1422-0067/20/5/1254

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