One-Step Construction of 1,3,4-Oxadiazoles with Anticancer Activity from Tertiary Amines via a Sequential Copper(I)-Catalyzed Oxidative Ugi/aza-Wittig Reaction

One-Step Construction of 1,3,4-Oxadiazoles with Anticancer Activity from Tertiary Amines via a Sequential Copper(I)-Catalyzed Oxidative Ugi/aza-Wittig Reaction

An unparalleled copper(I)-catalyzed synthesis of 1,3,4-oxadiazoles from tertiary amines in one step has been described. The one-pot reactions involving (N-isocyanimine)triphenylphosphorane, tertiary amines, and carboxylic acids resulted in the formation of 1,3,4-oxadiazoles in moderate to good yield...

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Bibliographic Details
Main Authors: Mei Sun, Nong-Qi Mao, Sheng-Long Wang, Xin-Ming Han, Gang Yao, Ping Xue, Chong-Yang Zeng, Yu-Ting Liu, Kai Chen, Xiao-Qing Gao, Jun Xiong
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Molecules
Subjects:
1,3,4-oxadiazole
Cu-catalyzed
C-H functionalization
oxidative Ugi reaction
aza-Wittig reaction
anticancer
Online Access:https://www.mdpi.com/1420-3049/29/6/1253

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https://www.mdpi.com/1420-3049/29/6/1253

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