Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer

Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer

Understanding the immune compartment of tumors facilitates the development of revolutionary new therapies. We used a Kras(G12D)-driven mouse model of lung cancer to establish an immune signature and identified a contribution of Gr1+ neutrophils to disease progression. Depletion experiments showed th...

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Bibliographic Details
Main Authors: Julien Faget, Svenja Groeneveld, Gael Boivin, Martial Sankar, Nadine Zangger, Miguel Garcia, Nicolas Guex, Inti Zlobec, Loïc Steiner, Alessandra Piersigilli, Ioannis Xenarios, Etienne Meylan
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Cell Reports
Subjects:
lung cancer
neutrophil
MegaClust
vascularization
hypoxia
immunotherapy
PD1
immune exclusion
Snail
CXCL2
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717317047

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http://www.sciencedirect.com/science/article/pii/S2211124717317047

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