Targeted therapy for a subset of acute myeloid leukemias that lack expression of aldehyde dehydrogenase 1A1

Targeted therapy for a subset of acute myeloid leukemias that lack expression of aldehyde dehydrogenase 1A1

Aldehyde dehydrogenase 1A1 (ALDH1A1) activity is high in hematopoietic stem cells and functions in part to protect stem cells from reactive aldehydes and other toxic compounds. In contrast, we found that approximately 25% of all acute myeloid leukemias expressed low or undetectable levels of ALDH1A1...

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Bibliographic Details
Main Authors: Maura Gasparetto, Shanshan Pei, Mohammad Minhajuddin, Nabilah Khan, Daniel A. Pollyea, Jason R. Myers, John M. Ashton, Michael W. Becker, Vasilis Vasiliou, Keith R. Humphries, Craig T. Jordan, Clayton A. Smith
Format: Article
Language:English
Published: Ferrata Storti Foundation 2017-06-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/8096

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https://haematologica.org/article/view/8096

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