Double-jeopardy: scRNA-seq doublet/multiplet detection using multi-omic profiling

Summary: The computational detection and exclusion of cellular doublets and/or multiplets is a cornerstone for the identification the true biological signals from single-cell RNA sequencing (scRNA-seq) data. Current methods do not sensitively identify both heterotypic and homotypic doublets and/or m...

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Bibliographic Details
Main Authors: Bo Sun, Emmanuel Bugarin-Estrada, Lauren Elizabeth Overend, Catherine Elizabeth Walker, Felicia Anna Tucci, Rachael Jennifer Mary Bashford-Rogers
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Cell Reports: Methods
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2667237521000084