Novel nucleotide and amino acid covariation between the 5'UTR and the NS2/NS3 proteins of hepatitis C virus: bioinformatic and functional analyses.

Novel nucleotide and amino acid covariation between the 5'UTR and the NS2/NS3 proteins of hepatitis C virus: bioinformatic and functional analyses.

Molecular covariation of highly polymorphic viruses is thought to have crucial effects on viral replication and fitness. This study employs association rule data mining of hepatitis C virus (HCV) sequences to search for specific evolutionary covariation and then tests functional relevance on HCV rep...

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Bibliographic Details
Main Authors: Hung-Yu Sun, Nai-Ying Ou, Shainn-Wei Wang, Wen-Chun Liu, Ting-Fang Cheng, Shiou-Jiuan Shr, Koun-Tem Sun, Ting-Tsung Chang, Kung-Chia Young
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3182228?pdf=render

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http://europepmc.org/articles/PMC3182228?pdf=render

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