Sulfur Amino Acid Supplementation Abrogates Protective Effects of Caloric Restriction for Enhancing Bone Marrow Regrowth Following Ionizing Radiation

Sulfur Amino Acid Supplementation Abrogates Protective Effects of Caloric Restriction for Enhancing Bone Marrow Regrowth Following Ionizing Radiation

Radiation therapy damages and depletes total bone marrow (BM) cellularity, compromising safety and limiting effective dosing. Aging also strains total BM and BM hematopoietic stem and progenitor cell (HSPC) renewal and function, resulting in multi-system defects. Interventions that preserve BM and B...

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Bibliographic Details
Main Authors: Christopher Hine, J. Humberto Treviño-Villarreal, Pedro Mejia, Alban Longchamp, Lear E. Brace, Eylul Harputlugil, Sarah J. Mitchell, Jie Yang, Yihong Guan, Jaroslaw P. Maciejewski, Babal K. Jha, James R. Mitchell
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Nutrients
Subjects:
caloric restriction (CR)
fasting
bone marrow
radioprotection
cystathionine γ-lyase (CGL)
hydrogen sulfide (H<sub>2</sub>S)
Online Access:https://www.mdpi.com/2072-6643/14/7/1529

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https://www.mdpi.com/2072-6643/14/7/1529

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