Chemotherapy and Stem Cell Transplantation Increase p16INK4a Expression, a Biomarker of T-cell Aging

Chemotherapy and Stem Cell Transplantation Increase p16INK4a Expression, a Biomarker of T-cell Aging

The expression of markers of cellular senescence increases exponentially in multiple tissues with aging. Age-related physiological changes may contribute to adverse outcomes in cancer survivors. To investigate the impact of high dose chemotherapy and stem cell transplantation on senescence markers i...

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Bibliographic Details
Main Authors: William A. Wood, Janakiraman Krishnamurthy, Natalia Mitin, Chad Torrice, Joel S. Parker, Anna C. Snavely, Thomas C. Shea, Jonathan S. Serody, Norman E. Sharpless
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:EBioMedicine
Subjects:
Aging
Senescence
Exhaustion
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416303784

Internet

http://www.sciencedirect.com/science/article/pii/S2352396416303784

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