Activation of <i>Anopheles stephensi</i> Pantothenate Kinase and Coenzyme A Biosynthesis Reduces Infection with Diverse <i>Plasmodium</i> Species in the Mosquito Host

Activation of <i>Anopheles stephensi</i> Pantothenate Kinase and Coenzyme A Biosynthesis Reduces Infection with Diverse <i>Plasmodium</i> Species in the Mosquito Host

Malaria parasites require pantothenate from both human and mosquito hosts to synthesize coenzyme A (CoA). Specifically, mosquito-stage parasites cannot synthesize pantothenate de novo or take up preformed CoA from the mosquito host, making it essential for the parasite to obtain pantothenate from mo...

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Bibliographic Details
Main Authors: Raquel M. Simão-Gurge, Neha Thakre, Jessica Strickland, Jun Isoe, Lillian R. Delacruz, Brandi K. Torrevillas, Anna M. Rodriguez, Michael A. Riehle, Shirley Luckhart
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Biomolecules
Subjects:
coenzyme A
CoA
pantothenate kinase
PanK
<i>Anopheles stephensi</i>
midgut
Online Access:https://www.mdpi.com/2218-273X/11/6/807

Internet

https://www.mdpi.com/2218-273X/11/6/807

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