A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancer

A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancer

Standard treatment for metastatic prostate cancer (CaP) prevents ligand-activation of androgen receptor (AR). Despite initial remission, CaP progresses while relying on AR. AR transcriptional output controls CaP behavior and is an alternative therapeutic target, but its molecular regulation is poorl...

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Bibliographic Details
Main Authors: Song Liu, Sangeeta Kumari, Qiang Hu, Dhirodatta Senapati, Varadha Balaji Venkadakrishnan, Dan Wang, Adam D DePriest, Simon E Schlanger, Salma Ben-Salem, Malyn May Valenzuela, Belinda Willard, Shaila Mudambi, Wendy M Swetzig, Gokul M Das, Mojgan Shourideh, Shahriah Koochekpour, Sara Moscovita Falzarano, Cristina Magi-Galluzzi, Neelu Yadav, Xiwei Chen, Changshi Lao, Jianmin Wang, Jean-Noel Billaud, Hannelore V Heemers
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
transcription
castration-resistant
androgen deprivation therapy
castration
coactivator
corepressor
Online Access:https://elifesciences.org/articles/28482

Internet

https://elifesciences.org/articles/28482

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