Transcriptomic changes in the large organs in lethal meningococcal shock are reflected in a porcine shock model

Transcriptomic changes in the large organs in lethal meningococcal shock are reflected in a porcine shock model

BackgroundFulminant meningococcal sepsis with shock and multiple organ failure is associated with a massive systemic inflammatory response involving solid organs. We have previously established a porcine model of the disease to study pathophysiologic and possible therapeutic strategies.ObjectiveThis...

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Bibliographic Details
Main Authors: Berit Sletbakk Brusletto, Bernt Christian Hellerud, Ole Kristoffer Olstad, Reidun Øvstebø, Petter Brandtzaeg
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Neisseria meningitidis
meningococcal septic shock
porcine shock model
organ specific transcriptional profile
IPA comparison analysis
disseminated intravascular coagulation (DIC)
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.908204/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.908204/full

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