Anemoside B4 attenuates RANKL-induced osteoclastogenesis by upregulating Nrf2 and dampens ovariectomy-induced bone loss

Anemoside B4 attenuates RANKL-induced osteoclastogenesis by upregulating Nrf2 and dampens ovariectomy-induced bone loss

Increased numbers and functional overactivity of osteoclasts are the pathological basis for bone loss diseases such as osteoporosis, which are characterized by cortical bone thinning, decreased trabecular bone quantity, and reduced bone mineral density. Effective inhibition of osteoclast formation a...

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Bibliographic Details
Main Authors: Zhen Cao, Xuben Niu, Maihuan Wang, Siwang Yu, Mingkun Wang, Silong Mu, Chuan Liu, Yaxi Wang
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Anemoside B4
Osteoclastogenesis
Bone resorption
Nrf2
Osteoporosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223012520

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http://www.sciencedirect.com/science/article/pii/S0753332223012520

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