The Number of MRGPRX2-Expressing Cells Is Increased in Skin Lesions of Patients With Indolent Systemic Mastocytosis, But Is Not Linked to Symptom Severity

The Number of MRGPRX2-Expressing Cells Is Increased in Skin Lesions of Patients With Indolent Systemic Mastocytosis, But Is Not Linked to Symptom Severity

BackgroundRecently, the expression of the mast cell (MC) receptor Mas-related G protein–coupled receptor X2 (MRGPRX2) has been detected in lesional skin of adult patients with cutaneous mastocytosis. As of yet, little is known about the clinical relevance of MRGPRX2 and its agonists in patients with...

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Bibliographic Details
Main Authors: Polina Pyatilova, Tameem Ashry, Yanyan Luo, Jiajun He, Hanna Bonnekoh, Qingqing Jiao, Sherezade Moñino-Romero, Man Hu, Jörg Scheffel, Stefan Frischbutter, Maud A. W. Hermans, Bradford A. Youngblood, Marcus Maurer, Frank Siebenhaar, Pavel Kolkhir
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
MRGPRX2
cortistatin
mastocytosis
mast cell
mRNA
major basic protein (MBP)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.930945/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.930945/full

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