The 3-phosphoinositide-dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites.

The 3-phosphoinositide-dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites.

Cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) signalling is essential for the proliferation of Plasmodium falciparum malaria blood stage parasites. The mechanisms regulating the activity of the catalytic subunit PfPKAc, however, are only partially understood, and PfPKAc func...

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Bibliographic Details
Main Authors: Eva Hitz, Natalie Wiedemar, Armin Passecker, Beatriz A S Graça, Christian Scheurer, Sergio Wittlin, Nicolas M B Brancucci, Ioannis Vakonakis, Pascal Mäser, Till S Voss
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-12-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001483

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https://doi.org/10.1371/journal.pbio.3001483

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