Integrated compact regulators of protein activity enable control of signaling pathways and genome-editing in vivo
Abstract Viral proteases and clinically safe inhibitors were employed to build integrated compact regulators of protein activity (iCROP) for post-translational regulation of functional proteins by tunable proteolytic activity. In the absence of inhibitor, the co-localized/fused protease cleaves a ta...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2024-01-01
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| Series: | Cell Discovery |
| Online Access: | https://doi.org/10.1038/s41421-023-00632-1 |