Cytoplasmic and Nuclear TAZ Exert Distinct Functions in Regulating Primed Pluripotency

Cytoplasmic and Nuclear TAZ Exert Distinct Functions in Regulating Primed Pluripotency

Mouse epiblast stem cells (mEpiSCs) and human embryonic stem cells (hESCs) are primed pluripotent stem cells whose self-renewal can be maintained through cytoplasmic stabilization and retention of β-catenin. The underlying mechanism, however, remains largely unknown. Here, we show that cytoplasmic β...

Full description

Bibliographic Details
Main Authors: Xingliang Zhou, Jean Paul Chadarevian, Bryan Ruiz, Qi-Long Ying
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Stem Cell Reports
Subjects:
β-catenin
TAZ
Hippo pathway
Wnt signaling pathway
epiblast stem cell
human embryonic stem cell
primed pluripotency
stem cell self-renewal
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117303296

Internet

http://www.sciencedirect.com/science/article/pii/S2213671117303296

Similar Items