Computational protein design approaches with significant biological outcomes: progress and challenges

Enzymes are powerful biocatalysts, however, so far there is still a large gap between the number of enzyme-based practical applications and that of naturally occurring enzymes. Multiple experimental approaches have been applied to generate nearly all possible mutations of target enzymes, allowing th...

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Bibliographic Details
Main Authors: Xiaoman Li, Ziding Zhang, Jiangning Song
Format: Article
Language:English
Published: Elsevier 2012-09-01
Series:Computational and Structural Biotechnology Journal
Online Access:http://journals.sfu.ca/rncsb/index.php/csbj/article/view/csbj.201209007