Chronic PPARγ Stimulation Shifts Amyloidosis to Higher Fibrillarity but Improves Cognition

Chronic PPARγ Stimulation Shifts Amyloidosis to Higher Fibrillarity but Improves Cognition

We undertook longitudinal β-amyloid positron emission tomography (Aβ-PET) imaging as a translational tool for monitoring of chronic treatment with the peroxisome proliferator-activated receptor gamma (PPARγ) agonist pioglitazone in Aβ model mice. We thus tested the hypothesis this treatment would re...

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Bibliographic Details
Main Authors: Tanja Blume, Maximilian Deussing, Gloria Biechele, Finn Peters, Benedikt Zott, Claudio Schmidt, Nicolai Franzmeier, Karin Wind, Florian Eckenweber, Christian Sacher, Yuan Shi, Katharina Ochs, Gernot Kleinberger, Xianyuan Xiang, Carola Focke, Simon Lindner, Franz-Josef Gildehaus, Leonie Beyer, Barbara von Ungern-Sternberg, Peter Bartenstein, Karlheinz Baumann, Helmuth Adelsberger, Axel Rominger, Paul Cumming, Michael Willem, Mario M. Dorostkar, Jochen Herms, Matthias Brendel
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
pioglitazone
Aβ-PET
AppNL–G–F mice
PS2APP mice
microglia
Aβ-plaque composition
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.854031/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2022.854031/full

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