Cell-specific transcriptome changes in the hypothalamic arcuate nucleus in a mouse deoxycorticosterone acetate-salt model of hypertension

Cell-specific transcriptome changes in the hypothalamic arcuate nucleus in a mouse deoxycorticosterone acetate-salt model of hypertension

A common preclinical model of hypertension characterized by low circulating renin is the “deoxycorticosterone acetate (DOCA)-salt” model, which influences blood pressure and metabolism through mechanisms involving the angiotensin II type 1 receptor (AT1R) in the brain. More specifically, AT1R within...

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Bibliographic Details
Main Authors: Valerie A. Wagner, Guorui Deng, Kristin E. Claflin, McKenzie L. Ritter, Huxing Cui, Pablo Nakagawa, Curt D. Sigmund, Lisa L. Morselli, Justin L. Grobe, Anne E. Kwitek
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
snRNAseq
DOCA-salt
arcuate nucleus
AgRP neurons
microglia
mouse
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1207350/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2023.1207350/full

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