Deregulation of Mitochondrial Calcium Handling Due to Presenilin Loss Disrupts Redox Homeostasis and Promotes Neuronal Dysfunction

Deregulation of Mitochondrial Calcium Handling Due to Presenilin Loss Disrupts Redox Homeostasis and Promotes Neuronal Dysfunction

Mitochondrial dysfunction and oxidative stress are major contributors to the pathophysiology of neurodegenerative diseases, including Alzheimer’s disease (AD). However, the mechanisms driving mitochondrial dysfunction and oxidative stress are unclear. Familial AD (fAD) is an early onset form of AD c...

Full description

Bibliographic Details
Main Authors: Kerry C. Ryan, Jocelyn T. Laboy, Kenneth R. Norman
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Antioxidants
Subjects:
Alzheimer’s disease
oxidative stress
presenilin
mitochondria
calcium
neuronal dysfunction
Online Access:https://www.mdpi.com/2076-3921/11/9/1642

Internet

https://www.mdpi.com/2076-3921/11/9/1642

Similar Items