The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson’s disease

The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson’s disease

Astrocytes are essential cells of the central nervous system, characterized by dynamic relationships with neurons that range from functional metabolic interactions and regulation of neuronal firing activities, to the release of neurotrophic and neuroprotective factors. In Parkinson’s disease (PD), d...

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Bibliographic Details
Main Authors: Aurelie de Rus Jacquet, Jenna L Tancredi, Andrew L Lemire, Michael C DeSantis, Wei-Ping Li, Erin K O'Shea
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-09-01
Series:eLife
Subjects:
neurodegenerative diseases
neuron-glia interactions
non-cell autonomous
neurodegeneration
Parkinson's disease
exosomes
Online Access:https://elifesciences.org/articles/73062

Internet

https://elifesciences.org/articles/73062

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