Resveratrol as a pan-HDAC inhibitor alters the acetylation status of histone [corrected] proteins in human-derived hepatoblastoma cells.

The polyphenolic alcohol resveratrol has demonstrated promising activities for the prevention and treatment of cancer. Different modes of action have been described for resveratrol including the activation of sirtuins, which represent the class III histone deacetylases (HDACs). However, little is kn...

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Main Authors: Sascha Venturelli, Alexander Berger, Alexander Böcker, Christian Busch, Timo Weiland, Seema Noor, Christian Leischner, Sabine Schleicher, Mascha Mayer, Thomas S Weiss, Stephan C Bischoff, Ulrich M Lauer, Michael Bitzer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24023672/pdf/?tool=EBI