Generation of Phenothiazine with Potent Anti-TLK1 Activity for Prostate Cancer Therapy

Generation of Phenothiazine with Potent Anti-TLK1 Activity for Prostate Cancer Therapy

Summary: Through in vitro kinase assays and docking studies, we report the synthesis and biological evaluation of a phenothiazine analog J54 with potent TLK1 inhibitory activity for prostate cancer (PCa) therapy. Most PCa deaths result from progressive failure in standard androgen deprivation therap...

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Bibliographic Details
Main Authors: Vibha Singh, Siddhant Bhoir, Rupesh V. Chikhale, Javeena Hussain, Donard Dwyer, Richard A. Bryce, Sivapriya Kirubakaran, Arrigo De Benedetti
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:iScience
Subjects:
Medical Biochemistry
Structural Biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220306660

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http://www.sciencedirect.com/science/article/pii/S2589004220306660

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