A high ratio of linoleic acid (n-6 PUFA) to alpha-linolenic acid (n-3 PUFA) adversely affects early stage of human neuronal differentiation and electrophysiological activity of glutamatergic neurons in vitro

A high ratio of linoleic acid (n-6 PUFA) to alpha-linolenic acid (n-3 PUFA) adversely affects early stage of human neuronal differentiation and electrophysiological activity of glutamatergic neurons in vitro

Introduction: There is a growing interest in the possibility of dietary supplementation with polyunsaturated fatty acids (PUFAs) for treatment and prevention of neurodevelopmental and neuropsychiatric disorders. Studies have suggested that of the two important classes of polyunsaturated fatty acids,...

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Bibliographic Details
Main Authors: Karolina Dec, Mouhamed Alsaqati, Joanne Morgan, Sumukh Deshpande, Jamie Wood, Jeremy Hall, Adrian J. Harwood
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
polyunsaturated fatty acids
neurodevelopment
human induced pluripotent stem cells
linoleic acid
alpha-linolenic acid
GABA signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1166808/full

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https://www.frontiersin.org/articles/10.3389/fcell.2023.1166808/full

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