Pharmacological inhibition of ABCA1 degradation increases HDL biogenesis and exhibits antiatherogenesis[S]

Pharmacological inhibition of ABCA1 degradation increases HDL biogenesis and exhibits antiatherogenesis[S]

Expression of ABCA1 is regulated by transcription of the gene and calpain-mediated proteolytic degradation, and inhibition ABCA1 degradation results in increased ABCA1 and HDL biogenesis in vitro. We examined whether this approach could be a potential antiatherogenic treatment. Although probucol inh...

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Bibliographic Details
Main Authors: Reijiro Arakawa, Maki Tsujita, Noriyuki Iwamoto, Chisato Ito-Ohsumi, Rui Lu, Chen-Ai Wu, Kenji Shimizu, Tomoji Aotsuka, Hashime Kanazawa, Sumiko Abe-Dohmae, Shinji Yokoyama
Format: Article
Language:English
Published: Elsevier 2009-11-01
Series:Journal of Lipid Research
Subjects:
ATP binding cassette transporter A1
high density lipoprotein
atherosclerosis
calpain
probucol
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520306969

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http://www.sciencedirect.com/science/article/pii/S0022227520306969

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