Molecular Determinants for OMF Selectivity in Tripartite RND Multidrug Efflux Systems

Molecular Determinants for OMF Selectivity in Tripartite RND Multidrug Efflux Systems

Tripartite multidrug RND efflux systems made of an inner membrane transporter, an outer membrane factor (OMF) and a periplasmic adaptor protein (PAP) form a canal to expel drugs across Gram-negative cell wall. Structures of MexA–MexB–OprM and AcrA–AcrB–TolC, from <i>Pseudomonas aeruginosa</...

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Bibliographic Details
Main Authors: Esther Boyer, Jean Dessolin, Margaux Lustig, Marion Decossas, Gilles Phan, Quentin Cece, Grégory Durand, Véronique Dubois, Joris Sansen, Jean-Christophe Taveau, Isabelle Broutin, Laetitia Daury, Olivier Lambert
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Antibiotics
Subjects:
antibiotic resistance
efflux pump
RND
Online Access:https://www.mdpi.com/2079-6382/11/2/126

Internet

https://www.mdpi.com/2079-6382/11/2/126

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