Silica nanocarrier-mediated intracellular delivery of rapamycin promotes autophagy-mediated M2 macrophage polarization to regulate bone regeneration

Silica nanocarrier-mediated intracellular delivery of rapamycin promotes autophagy-mediated M2 macrophage polarization to regulate bone regeneration

Targeting macrophages to regulate the immune microenvironment is a new strategy for bone regeneration with nano-drugs. Nano-drugs have achieved surprising anti-inflammatory and bone-regenerative effects, however, their underlying mechanisms in macrophages remain to be clarified. Macrophage polarizat...

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Bibliographic Details
Main Authors: Qing Zhang, Mengyu Xin, Shuang Yang, Qiuyu Wu, Xi Xiang, Tianqi Wang, Wen Zhong, Marco N. Helder, Richard T. Jaspers, Janak Lal Pathak, Yin Xiao
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Materials Today Bio
Subjects:
Autophagy
Rapamycin
Hollow silica nanoparticles
Macrophages
Osteogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006423000832

Internet

http://www.sciencedirect.com/science/article/pii/S2590006423000832

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