Secondary structure of the human mitochondrial genome affects formation of deletions

Secondary structure of the human mitochondrial genome affects formation of deletions

Abstract Background Aging in postmitotic tissues is associated with clonal expansion of somatic mitochondrial deletions, the origin of which is not well understood. Such deletions are often flanked by direct nucleotide repeats, but this alone does not fully explain their distribution. Here, we hypot...

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Bibliographic Details
Main Authors: Victor Shamanskiy, Alina A. Mikhailova, Evgenii O. Tretiakov, Kristina Ushakova, Alina G. Mikhailova, Sergei Oreshkov, Dmitry A. Knorre, Natalia Ree, Jonathan B. Overdevest, Samuel W. Lukowski, Irina Gostimskaya, Valerian Yurov, Chia-Wei Liou, Tsu-Kung Lin, Wolfram S. Kunz, Alexandre Reymond, Ilya Mazunin, Georgii A. Bazykin, Jacques Fellay, Masashi Tanaka, Konstantin Khrapko, Konstantin Gunbin, Konstantin Popadin
Format: Article
Language:English
Published: BMC 2023-05-01
Series:BMC Biology
Subjects:
Mitochondrial DNA
Deletions
Aging
Single-stranded DNA
Global secondary structure
Contact zone
Online Access:https://doi.org/10.1186/s12915-023-01606-1

Internet

https://doi.org/10.1186/s12915-023-01606-1

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